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WHAT DOES CBD DO? CBD OIL AND ITS EFFECTS

What does CBD do? What does CBD stand for? Cannabidiol, or CBD, is a chemical compound found in the Cannabis sativa plant. Initially discovered in 1940, cannabidiol is a phytocannabinoid (the chemical compounds naturally found in Marijuana and Hemp plants). Despite this fact, CBD does not create any psychological effects, unlike the cannabinoid THC. Out of the 113 or more cannabinoids found in Cannabis plants, cannabidiol accounts for approximately 10-15% of the plants’ extract.

Clinical research has been investigating the positive health benefits of CBD, finding that CBD could be used to ease or remedy the symptoms of common health issues like anxiety, depression, acne, and heart disease. It may even stand as a natural alternative for pain and symptom relief when dealing with cancer.

It’s no wonder that CBD has swept through the American consumer market. Google trends and search data have proven that CBD is gradually becoming a household name. Everyone wants to know about CBD, from what it can do, its safeness for use, and the total extent of its effects. This article aims to answer some of these common questions while also discussing current scientific data on CBD use.

Does CBD oil make you high?

The most common misconceptions about CBD are based on the question, “Are CBD and Marijuana the same thing?”

In short, no. While CBD is an essential compound of cannabis found in both Hemp and Marijuana plants, you cannot get high from using CBD. A report by the World Health Organization states that ”in humans, CBD exhibits no effects indicative of any abuse or dependence potential…to date, there is no evidence of public health-related problems associated with the use of pure CBD.”

What part of cannabis does make you get high?

The psychological effects are colloquially known as “getting high” come from another cannabinoid called THC. The THC attaches to cannabinoid receptors in the brain, which then creates the psychoactive effects most people associate with Marijuana use.

CBD vs. THC

Both compounds are part of the Cannabis plant, but high concentrations of THC are only found in Marijuana. The Hemp plant is defined as those varieties that contain less than 0.3% THC, so it cannot create a high. CBD is found in both types of Cannabis; however, the Hemp plant is used more commonly for CBD oil extraction.

Are CBD and THC legal?

In terms of legality, CBD is readily available for purchase in America thanks to the 2018 Farm Bill. The bill included a provision that federally legalized Hemp for agricultural production, so long as it contains no more than 0.3 percent THC, a level that will not do not make the user get high. This allowed the CBD-only industry to take off, and now CBD can be purchased online and in all 50 states.

Marijuana, on the other hand, is legal for sale and consumption in only a handful of states in the U.S. due to its THC content. Although THC containing materials above 0.3% are still considered a Schedule 1 controlled substance by the federal government, medical Marijuana is legal in 33 states, and recreational Marijuana is legal in 11 states plus the District of Columbia.

Eight Scientific Health Benefits CBD Oil

As noted, studies on CBD have proven it can provide relief from many different ailments and symptoms. CBD has also been touted as a supplement for other general health and wellness issues. Despite CBD being somewhat controversial or misunderstood, it is imperative to understand that CBD is considered safe for human use, as it contains zero addictive properties or elements that get you high, such as the THC compound found in Marijuana.

Thus far, scientific research on CBD has demonstrated it has the potential to provide the following benefits to its users:

1. Relieves chronic pain and inflammation

CBD may offer an alternative to moderating some types of chronic pain. Many people who have fibromyalgia have affirmed that they felt relief after using cannabidiol oil. Further studies have proven mechanisms by which cannabidiol oils inhibit inflammatory and neurotic pain. Using an animal model, a study from the European Journal of Pain demonstrated that CBD oil, when applied to the skin, could help lower pain and inflammation as a result of arthritis.

More research is needed to confirm these benefits for humans further. However, many CBD oil users claim that it does reduce pain and inflammation caused by various chronic health conditions.

2. Calms or stops epilepsy

Videos showing the beneficial effects of CBD on children with epilepsy are found all over the internet. Many studies have shown that cannabidiol possesses anti-seizure properties that can effectively treat children with drug-resistant forms of epilepsy. A study published in the New England Journal of Medicine revealed that CBD use reduced the occurrence of seizures by 23 percent over those taking a placebo.

New research has explored using CBD to treat some of the cruelest childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS). Typically, these syndromes do not respond to anti-seizure medicines. However, in many of the research cases, cannabidiol oil decreased the number of seizures the patient suffered and eliminated seizures in others.

In June 2018, the FDA approved Epidiolex, the first cannabis-derived medicine containing cannabidiol, to treat these severe conditions. Epidiolex also happens to be the first FDA-approved drug that contains a purified form of a Marijuana extract. The drug mitigates the seizures and sometimes gets rid of them entirely. Panacea Life Sciences manufactures a similar version of this product since it is naturally produced from the Hemp plant.

3. Reduces oxidative stress

Oxidative stress is caused when the body has an excess of free radicals, which are molecules that contain an uneven number of electrons as well as oxygen. In periods of oxidative stress, the body’s antioxidants are unable to neutralize all the free radicals. This health issue is relatively new due to increased environmental toxicity around the world.

4. Regulates blood pressure

Heart disease is one of the top causes of death in the United States. High blood pressure can cause hypertensive heart disease because it affects how the heart’s arteries and muscles work. High blood pressure increases the amount of work the heart has to do to pump blood throughout the body, which can lead to the heart becoming enlarged. Oftentimes hypertension is associated with an increased risk for stroke and kidney disease. A 2017 study published in JCI Insight revealed that CBD could help regulate blood pressure fluctuations engendered by stress. Thus, CBD may be used as a preventative measure for heart health.

5. Fights multi-resistant bacteria

CBD has the unconventional means to fight certain kinds of bacteria, typically the drug-resistant strains. In one study, CBD was found to be bactericidal against strains of staphylococci and streptococci. A 2011 study showed that cannabidiol could reduce the tuberculosis progression found in rats; however, the study found that this may be because of slowed the increase of T cells. More research is required to better understand cannabidiol’s role in fighting infections.

6. Treats symptoms of Type 1 diabetes

Type 1 diabetes occurs when the body’s immune system attacks the pancreatic cells that produce insulin, which then causes inflammation. Research by Clinical Hemorheology and Microcirculation in 2016 showed that cannabidiol could ease pancreatic inflammation and lowered the occurrences of Type 1 diabetes in mice.

7. Alleviates skin conditions

Numerous studies have proven that CBD can clear up skin issues like eczema by encouraging unconventional cell death. CBD can also regulate excess sebum (oil) production, which helps to prevent acne. Coupled with its anti-inflammatory properties, CBD can be an effective anti-oxidant in skin care, much like vitamins C or E.

8. May slow progression of Alzheimer’s disease

The Journal of Alzheimer’s Disease published a study in 2014, showing CBD can slow the growth of social recognition memory deficit in people in the early stages of Alzheimer’s. This means CBD may help improve their sense of recognizing familiar faces. It is also an effective way to make the symptoms of the disease less intense.

Is CBD oil safe?

CBD oil, to a large extent, has been shown to treat symptoms of many different ailments and is generally regarded as safe (GRAS) for human use. Adverse side effects of CBD are mild and rare, largely depending on dosage levels and the individual user. The side effects may include nausea, fatigue, and irritability. Cannabidiol can also raise levels of coumadin, a blood thinner, or impact levels of other medications in the blood.

However, as demonstrated above, scientific research has shown that cannabidiol helps treat specific ailments and provides relief for other everyday conditions and irritations.

Takeaway

It’s clear from the research on CBD that it interacts positively with the body. CBD oil can provide relief for specific conditions and symptoms while also providing general health and wellness benefits to its users. If you’re considering trying the supplement and you’re on other medication, be sure to consult with your doctor for proper guidance.

References:
Ministry Of Hemp
Drug Abuse
FDA
Health Line
Insight
Springer Link
NCBI
NCBI
NCBI

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Panacea’s Cannabinoid Research Center at Colorado State University makes revolutionary progress in year one

Panacea Life Sciences’ Cannabinoid Research Center (CRC) at Colorado State University (CSU) celebrates its first year of operation this month. With a mission of performing research to solve important industry issues and to better understand how cannabinoids work in the body, the center has made remarkable progress in its inaugural year. The CRC, established through collaboration between CSU and Panacea Life Sciences, consists of analytical chemistry and preparative chemistry technologies crucial for detection and purification of cannabinoids. Using these technologies, the CRC is able to remove common contaminants from hemp products, purify low concentration cannabinoids, and to support clinical studies.

The Center’s activities are coordinated by Boettcher Investigator Professor Melissa Reynolds with operations led by Jamie Cuchiaro, a Ph.D. candidate who will matriculate next month! A year ago, the CRC was a concept consisting of a new laboratory in the Colorado State University’s College of Natural Sciences and equipment still packed into crates. Over the last 12 months the laboratory has been extremely productive through initial analytical research and supporting numerous clinical studies in both dogs and humans.

 

Solving Industry Issues

Cannabis sativa L., or industrial hemp, is a cannabis plant strain specifically bred to contain low concentrations of tetrahydrocannabinol (THC) — less than 0.3%. THC is the psychogenic cannabinoid that causes the high associated with marijuana use. Due to its low propensity for inebriation and large economic impact to farmers and the health and wellness industries, industrial hemp was only recently legalized in the 2018 Farm Bill. The hemp plant is a hyperaccumulator, meaning trace elements in the soil in which the plant is grown, such as heavy metals, pesticides, and others, are readily absorbed in the plant, potentially contaminating hemp oil and rendering the material unusable. Pesticide contamination is a common issue with hemp growers. Although growers may use organic farming practices, a neighboring corn field sprayed with pesticides using a crop duster may drift the pesticide over the hemp field and be enough to result in substantial pesticide contamination. Using analytical techniques, graduate student, Jamie Cuchiaro has developed a method for complete removal of commonly used pesticides to remediate contaminated hemp oil to produce a safe and usable hemp product. This work has been submitted for publication to the Journal of Cannabis Research in August of this year.

 

Sustainability and Access to Minor Cannabinoids

The Cannabis plant has an incredibly rich chemical profile containing over 500 unique chemicals identified and over 120 cannabinoids. Of the cannabinoids, the best known due to their elevated expression in the plant, are CBD and THC. CBD, a non-psychogenic cannabinoid, is becoming commonly used by the health and wellness industry primarily as an anti-inflammatory. Each of the other 118 cannabinoids are anticipated to have unique and beneficial health benefits. The issue is determining how to obtain sufficient quantities and purity of the low concentration (minor) cannabinoids as they are present at less than 1% in hemp extracts.

One solution to obtaining sufficient quantities of minor cannabinoids has been developed in a collaboration between Panacea Life Sciences and the CRC. The process of distilling crude hemp oil into CBD distillates creates a byproduct mixture of fats, waxes, starches, and other components of the hemp plant that has the consistency and appearance of road tar. Typically, this material is thrown away to enter the waste stream. As a member of Colorado’s Environmental Leadership Program, Panacea wanted to find another use of this distillate byproduct by repurposing the material. In closer examination of the byproduct, the CRC determined that there are substantial minor cannabinoids such as cannabidivarin (CBDV), Cannabichromene (CBC), Cannabicyclol (CBL), and Cannabielsoin (CBE). The technology in the center will allow the group to further study these cannabinoids to better understand how these rare cannabinoids function in the body. This application of the CRC technology not only allows for access to these low abundance cannabinoids but also provides a solution to assist Panacea in attaining its sustainability goals by decreasing waste streams.

 

Supporting Clinical Trials

Two of the most common questions facing the industrial hemp industry are, what health benefits are provided by cannabinoids, and what concentrations/doses are needed to see health improvements? Although almost all CBD companies claim that CBD heals everything from Alzheimer’s to yeast infections, there is no guidance on dosing or really any concrete evidence that CBD does in fact help improve specific health conditions. Additionally, such companies also do not assert the measurement of how much CBD gets into the body to produce the stated effect. In order for a dietary supplement or drug to have effect in the body, a specific amount needs to be absorbed into the body. Cannabinoids, when taken orally, have very low bioavailability, meaning that less than 10% of the consumed dose will be absorbed into the body. Furthermore, the variability in bioavailability from one person to another can depend on whether cannabinoids are better absorbed when taken with or without food, individual genetics, and the dose form of the cannabinoid (edible, softgel, tablet, vape, liquid tincture, etc.). Taken together, this creates a confusing situation where cannabinoids such as CBD may work for some people and not others.

To gain further insight on cannabinoid activity, Panacea and the CRC are collaborating to launch specific clinical trials in several areas. Each study is supported by determination of the level of cannabinoids in the blood stream which will greatly improve the understanding of how cannabinoids as dietary supplements may provide health benefits. The first two studies have launched this year (2022):

  1. In collaboration with Dr. Stephanie McGrath and Dr. Julie Moreno, to examine CBD effects in a translational model of Alzheimer’s disease. In this study, performed in aged dogs that have cognitive impairment very similar to human AD, not only will CBD be evaluated for ability to slow disease progression, but will be one of the first studies to correlate how much consumed CBD enters the brain.
  2. In collaboration with Dr. Larry Good, a practicing gastroenterologist in New York, Panacea and the CRC have launched an open label study evaluating CBD and CBG for effects on irritable bowel syndrome, a condition affecting over 30 million American with no proven treatment.

The studies with doctors McGrath, Moreno, and Good, illustrate additional progress of the CRC to serve as a foundation for collaboration both within CSU as well as with other physicians and institutions. Additional collaborations in progress include that of Dr. Hollis Karoly (CSU) to explore CBD effects on anxiety and to support Dr. Karoly’s work on alcohol addiction, as well as with Camille Hoffman-Shuler at CU Anschutz to study the ability of cannabinoids to improve chronic pelvic pain and vulvodynia, a large unmet medical need in women’s health.

 

Looking Ahead

The CRC is actively working on expanding collaborations to progress research on various cannabinoids with a focus on improving health and addressing unmet medical needs. Collaborations to evaluate cannabinoids’ effects on various conditions, including exercise performance and recovery, gout, and even Post Traumatic Stress Disorder (PTSD), are underway. Panacea and the CRC also plan to work on improving methods for detecting cannabinoids as well as launching clinical studies for gout, eczema, rosacea, and acne, among others.

 

The progress made in the past year by the CRC has been tremendous and the future is extremely bright. With continued teamwork and direct studies, the CRC is poised to make even more revolutionary contributions to understanding how cannabinoids influence health and refining which conditions and doses are required for positive effects. Progress of the CRC will be posted as publications are submitted or clinical studies are completed on both the Colorado State University Panacea Life Sciences Cannabinoid Research Center webpage and at panacealife.com.

 

For any questions or comments, please reach out to [email protected].

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Why Doesn’t My Favorite Retailer Offer CBD Products?

With over 42% of Americans using over the counter CBD products to increase health and replace other dietary supplements or prescription medications, a common question is, why do these products need to be purchased online or at specialty CBD stores?1The lack of consistent regulations regarding how the Food and Drug Administration (FDA) and the Financial Industry Regulatory Authority (FINRA) view the hemp industry has restricted the ability of your favorite retailer to offer CBD products. Fortunately, recent bills and approvals are moving cannabidiol to mainstream acceptance, potentially allowing more convenient access to industrial hemp products.

Industrial hemp, or Cannabis sativa L., became federally legal with the approval of the 2018 Agriculture Improvement Act, more commonly referred to as the Farm Bill. Although this bill stated that hemp is legal to grow and products derived from industrial hemp were legal to make, there has been much confusion on how to tease apart the hemp industry from marijuana businesses. Because both industries work with Cannabis strains, the distinguishing feature between marijuana and hemp is the level of tetrahydrocannabinol (THC), the psychogenic compound found in the plant which by definition must be lower than 0.3% for industrial hemp, adding to the confusion among existing legal and regulatory frameworks.

Banking and Regulatory Roadblocks

 

Currently, marijuana containing greater than 0.3% THC is classified as a schedule 1 drug and is federally illegal. Although several states have enacted laws and regulation allowing the sale and production of marijuana, federal institutions such as the Drug Enforcement Agency (DEA) and FINRA view marijuana as an illegal drug that prohibits interstate commerce and banking to protect from drug money laundering. While the implications of banking restrictions are wide ranging, an important aspect is the lack of regulatory approval by FINRA does not allow major banks and credit card processors to accept marijuana transactions. Fair or not, hemp or CBD businesses have been lumped into marijuana banking restrictions. Relief is on the way though, as just last week, the SAFE (Secure and Fair Enforcement) Act was approved by the House of Representatives, and if this bill becomes a law, banking for both marijuana and hemp will be similar to legal businesses, allowing major retailers to consider offering CBD products to their consumer.

In parallel, the FDA has not provided guidance as to how CBD products should be classified. Since GW Pharma entered CBD into clinical trials in 1997, prior to the marketing or sale of CBD products, the FDA is obligated by law to consider CBD as a drug. Because there has been a large public interest with numerous companies selling CBD products in recent years, the FDA has been working to reconsider how to regulate CBD. Last year, FDA Commissioner Stephen Hahn stated, “People are using these [CBD] products. We’re not going to be able to say you can’t use these products. It’s a fool’s game to try to even approach that.” In the past year, the FDA has been working to determine the safety of CBD and explore how to regulate products containing this cannabinoid.

Regulation Matters

 

Proper regulations are extremely important for the over the counter CBD products industry so consumers are properly informed and products are made to potency and purity standards. Knowing how products are regulated is also important for retailers because it ensures proper labeling and helps to avoid product recalls, which are costly for both the retailer and product manufacturer. To this point, it is estimated that approximately 70% of Over the counter CBD products do not meet potency and purity requirements.2Many products do not contain the stated quantity of CBD in them and may even contain high levels of THC — not to mention the possibility of them also having impurities such as pesticides or heavy metals. With the FDA impasse on how to move forward, congress has introduced bill HR841 to provide legal authority for the FDA to regulate CBD as a dietary supplement.

This law would emulate the path taken by many progressive states that have embraced the CBD industry with set regulations. Colorado, for example, has enacted some of the best regulations for the hemp industry in the nation that provide clear guidance on how products will be manufactured and labeled. The Colorado regulations provide consumer information regarding products, protect the consumer from impure products, and allow a clear business approach for manufacturing. Likewise, California recently passed AB45 that legalizes the incorporation of hemp products into food, dietary supplements, cosmetics and pet products. While this bill is awaiting the governor’s signature, California’s Department of Health will consider how these products will be regulated within the state.

Overall, the past few months have provided more (much needed) clarity on the banking and regulatory pathways for CBD and industrial hemp products. Once the banking and regulatory definitions of hemp products are determined through various federal and state bills, retailers will begin carrying CBD products. This is a very important step allowing quality products to be made available to retailers while also allowing more Americans reliable and convenient access to the healing power of industrial hemp.

About the Author

James (Jamie) W. Baumgartner, Ph.D.

Born and raised in Eugene, Oregon, Dr. Baumgartner’s multitude of achievements span from holding 11 patents, to authoring well over 100 articles on the biological effects of cannabinoids in human and pet health, to working with state regulators to help shape the industrial hemp industry in Colorado working with both Colorado’s Department of Agriculture and Department of Health and Environment as a member of several of the Colorado Hemp Advancement and Management Plan. Jamie’s combined leadership, scientific and business expertise have led him to become the Chief Research Officer at Panacea Life Sciences, a Colorado-based, GMP certified, and vertically integrated cannabinoid

Reference Links:
1. MPG, Hemp-CBD Industry Overview, May 2020
2. FDA meeting June 2019
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Cannabidiol for Hair Growth

Androgenetic Alopecia (AGA), or hair loss, affects an estimated 50% of Caucasian men and 19% of Caucasian women, not using CBD for hair and skin have an increase in hair loss as people age. While this condition is not life threatening, Alopecia may negatively impact a person both psychologically and socially, especially in women.1All of us want to look and feel youthful, and a full head of hair is one trait valued for personal attractiveness. AGA is hypothesized to be caused by a variety of factors including the presence of dihydrotestosterone (DHT) in both men and women. In the United States, individuals spend more than $3.5 billion on hair loss products and procedures marketed to promote restoration of hair growth, many of which provide marginal improvements.2Although hemp extracts have had mixed reviews on effectiveness regarding hair growth, a recent study indicates that specific cannabinoids may help benefit hair loss and promote hair growth through topical applications.

Currently, two medications for CBD for hair and skin have been approved by the FDA for treatment of AGA: Minoxidil topical and oral Finasteride. Unfortunately, both medications offer limited results.3,4Minoxidil, a topical treatment that is a vasodilator, increases blood flow to the affected area of application and over a four-month treatment can increase hair growth up to 83% using a 3% solution.5Finasteride, a 5a-reductase inhibitor that was originally developed to treat men with benign prostate hyperplasia, decreases the ability of the body to produce testosterone. Finasteride at a dose of 1 mg/day increased hair growth by 14% after a one-year treatment.6Clinical studies are currently underway to explore the use of combinations of Minoxidil and Finasteride and whether combination of the two drugs may increase hair growth.7

How Does CBD Affect Hair Growth?

Interestingly, cannabinoids have been reported to also have effects on hair growth. Anecdotal and scientific publications have reported that cannabis extracts have both promoted hair loss as well as hair growth. A recent clinical publication exploring the effects of CBD-rich extracts helps to clarify prior seemingly contradictory information.8Cannabinoids, such as cannabidiol (CBD) and the psychogenic compound, tetrahydrocannabinol (THC), both exert biological effects through the body’s endocannabinoid system (ECS). The ECS is present throughout the body and is involved in maintaining cellular homeostasis in response to excess oxidative stress. Until recently, the ECS was thought to be comprised of only the CB1 and CB2 receptors, although subsequent studies have demonstrated that this definition needs to be redefined as cannabinoids interact with over 75 distinct receptors and enzymes.9,10,11

Studies have shown that the ECS is a key regulator of hair follicle cell growth and control. As shown in Figure 1, both CB1 and CB2 receptors are expressed in multiple skin cells, including hair follicles. Stimulation of the CB1 receptor leads to decreased hair shaft elongation, cell death, and hair follicle regression. The vanilloid receptor TRPV1 is located on hair matrix keratinocytes, and stimulation of this receptor also leads to hair follicle regression.12Examination of cannabinoid activity through these two receptors begins to explain the seemingly contradictory activity of cannabinoids when it comes to hair growth. THC stimulates CB1 and TRPV1 to result in hair loss, whereas CBD inhibits CB1 receptor activity and effectively shuts down TRPV1 signaling by causing fewer TRPV1 receptors to be present. Additionally, CBD for hair and skin has been described as an anti-inflammatory, so it may have indirect effects on hair growth through reduction of scalp inflammation.13

Figure 1. Cannabinoid effects on various skin cell types.

The Case for CBD

To demonstrate the effects of CBD on hair growth, researchers Gregory L. Smith and John Satino recruited 35 subjects (28 males and 7 females) that were provided a topical extract containing 54 mg CBD per ounce (also containing 1 mg/ounce of THC). The extract was applied daily for 14 weeks. The results demonstrated significant hair growth increases, similar to Minoxidil, of 74.1% in men and 55.2% in women. Longer times of treatment or studies to determine optimal dose of CBD have not been conducted. Because there is some uncertainty on whether higher doses of CBD would be beneficial, it certainly warrants more research. Additionally, the study did not address whether a full spectrum CBD-rich hemp extract is more effective than a THC-Non detect (<0.01% THC) extract. One may predict based on the molecular mechanism of activity described above, that elimination of the THC component would be beneficial to promoting hair growth. Since CBD works through a different mechanism than other known hair treatments such as Minoxidil and Finasteride, clinical studies should be conducted to explore whether these compounds may be used in combination to exert greater positive effects.

Currently, CBD and cannabinoids have been reported to have positive health benefits for numerous conditions. Although a majority of the results regarding CBD’s biological effects have not been examined by the FDA, nor are CBD products allowed to have claims on the prevention, diagnosis, or treatment of disease, the possibilities are exciting. People suffering from Androgenic Alopecia who have had poor results with existing medications or do not want to undergo hair transplant treatments, may wish to explore CBD to support scalp and hair health. Based on the G.L. Smith research, topicals should contain greater than 50 mg CBD per ounce and applied daily.

Panacea Life Sciences provides numerous industrial hemp products used to promote overall health and wellness. If you choose one of our topical CBD for hair and skin products, such as our Soothe salve or Transform lotion, let us know how the products work for you. Any questions or comments, please let us know by sending us an email to [email protected]

____

About the Author

James (Jamie) W. Baumgartner, Ph.D.

Born and raised in Eugene, Oregon, Dr. Baumgartner’s multitude of achievements span from holding 11 patents, to authoring well over 100 articles on the biological effects of cannabinoids in human and pet health, to working with state regulators to help shape the industrial hemp industry in Colorado working with both Colorado’s Department of Agriculture and Department of Health and Environment as a member of several of the Colorado Hemp Advancement and Management Plan. Jamie’s combined leadership, scientific and business expertise have led him to become the Chief Research Officer at Panacea Life Sciences, a Colorado-based, GMP certified, and vertically integrated cannabinoid company.

References:
1. Levy, L.L. et al. British Journal of Pharmacology (2015) v172 p4790
2. Global Hair Loss Treatment Market to Surpass US$ 5,461.1 Million at a CAGR of 6.2% during 2020-2027, Says Coherent Market Insights (CMI)
3. Gupta, A.K. & Charrett, A. Skinmed (2015) v 13 p185
4. Shapiro & Kaufman, K.D. Journal of Investigative Dermatology Symposium Proceedings (2018) v8 p20
5. Roberts, J.L. Journal of the American Academy of Dermatology (1987) v 16 p705
6. Shapiro, J. & Kaufman, K.D. Journal of Investigative Dermatology Symposium Proceedings (2003) v8 p20.
7. Suchonwanit, P. et al. Journal of the Eurpean Academy of Dermatology and Venereology (2018) v32 p. 2257.
8. Smith, G.L. & Satino, J. Cannabis (2021) v4 p53.
9. Ligresti, A., et al. Physiol. Rev. (2016) p 1593.
10. Bih, C.I., et al. Neurotherapeutics (2015) v 12 p699.
11. Panacea Life Sciences, unpublished data.
12. Telek, A. et al. The FASEB Journal (2007) v21 p3534.
13. Vincenzi, C. & Tosti A. Skin Appendage Disord. (2020) v6 p355.

Panacea Life Sciences Sponsors Colo. School of Mines CBD STEM Students

Panacea Life Sciences Sponsors Colo. School of Mines STEM Students to Explore Viability of Producing Graphene from Hemp

By exploring the use of hemp waste to produce graphene, an incredibly useful material, Panacea aims to improve sustainability while diversifying income streams

GOLDEN, CO, UNITED STATES, September 17, 2021 /EINPresswire.com/ — Exactus, Inc. (OTCQB:EXDI), soon to be Panacea Life Sciences, Inc. (OTCQB:PLSH)(the “Company”), a cGMP certified, vertically integrated premium CBD stem science company located in Golden, Colorado, has agreed to sponsor groups of chemical engineering students at the Colorado School of Mines, a prestigious research university focused on science and engineering and also located in Golden, Colorado, to explore the viability of using the company’s hemp waste to create the highly usable material, graphene. Through this project, Panacea is rewarded four-fold by pursuing the production of graphene, providing Mines’ students an opportunity to conduct research in a real-world scenario, improving sustainability by decreasing process energy waste from cannabidiol (CBD) product manufacturing, and diversifying income streams. Courses at the School of Mines employ these realistic, semester-long projects to give students an authentic industry experience, which provides the sponsoring companies innovative opportunities with minimal risk. Panacea’s Doug Grego, the New Project Development Manager will be mentoring two groups of 16 students throughout the fall semester.

“Senior-level design courses are a great chance for engineering students to get a taste of completing projects much like they will experience in their careers” accounts Grego. “Partnering with the School of Mines’ Chemical Engineers allows us to explore ways to reduce waste and expand the breadth of Industries that hemp can support, all while mentoring the next generation of environmentally conscious CBD stem science students.”
Hemp Plant Cross Section
Graphene is a material composed of only carbon atoms, arranged in a lattice structure that gives this material an extraordinary strength-to-weight ratio, but more importantly, makes graphene a great conductor of electricity. Graphene has potential use in a wide range of industries from energy storage to advanced electronics and even has uses in medicinal therapeutics.[1] It is projected that by 2026, the global graphene market will reach USD 221.4 million at a CAGR of 47.7%.[2] The goal for these teams of students is to design a process that converts hemp and hemp-waste into graphene oxide and/or other graphene products, using the spent hemp feedstocks from extraction processes and/or hemp biomass collected prior to extraction of hemp resins.

Panacea will own any intellectual property that comes out of the project which could offer them a starting point as they dive into new technologies. The biggest challenge the students face is figuring out if it is viable and cost-effective to separate the bast (the core of the hemp stalk) from the cannabinoid-rich inflorescence. Panacea’s Grego will be engaged with the groups weekly to answer questions, offer feedback, and to set expectations around project deliverables.
Graphene Breakdown
Sustainability is a large initiative for Panacea Life Sciences – something that differentiates the company from most others. The major sources of waste in the industry include chemical fertilizers, pesticides, fibrous waste, and packaging. Panacea is answering the call by never using chemical fertilizers or pesticides at their farm located on the western slope of Colorado, and they are in the process of implementing sustainable packaging by using product boxes made with recycled hemp. As a Silver Partner of the Colorado Department of Public Health and Environment’s (CDPHE) Environmental Leadership Program (ELP), as well as being Leadership in Energy and Environmental Design (LEED) certified under the U.S. Green Building Council (USGBC), Panacea has already implemented several sustainable practices and made a statement about their care and commitment to sustainability. The results of these projects at the School of Mines could very well help them to achieve an even higher accolade as they push to improve sustainability and minimize hemp waste while generating a new, high-functioning material such as graphene. | CBD stem science

Reference Links:
1 Safder, A., Kouzegaran, V. J., & Kutun, Ö. (n.d.). 60 uses of graphene – the ultimate guide to graphene's (potential) applications in 2019. Nanografi Nano Technology. Retrieved September 15, 2021, from https://nanografi.com/blog/60-uses-of-graphene/.
2 American Carbon Company. (n.d.). Retrieved September 15, 2021, from https://amcarbon.com/products/advanced-materials/graphene/graphene-types/.

Hemp Oil vs CBD Oil

Do you understand CBD? Know what it is? How it is used? You’ve probably read, heard, or have been in a conversation pertaining to the topic of CBD or at least heard it talked about. Whether researching it for yourself, a friend, a family member, or a furry friend, CBD has been a hot topic among folks who prefer a more holistic approach to life’s affairs. There is still little research on CBD oil and CBD hemp oil, but when looking to administer CBD, reading all that you can about the product and where it comes from is important. The difference between CBD oil and CBD hemp oil is not immense but important when searching for a CBD product.   In this article, Panacea Life Sciences will explain what CBD is, what is CBD Hemp oil, why one would use CBD oil, the differences of CBD products, and other useful topics to assist you in your CBD expedition.

What is (cannabidiol) CBD?

CBD or cannabidiol is one of the 113 cannabinoids found in the Cannabis plant.  It is the non-psychoactive component that many confuse with THC or tetrahydrocannabinol. This cannabinoid can be extracted separately from the THC and isn’t going to inebriate a user. There have been few studies, but many accounts of positive reactions from users of CBD for different purposes. CBD can be extracted from Cannabis plants, but these plants contain a higher percentage of THC. The hemp plants that are used to make CBD products must contain .3% THC or less. That limit is legally enforced in all 50 states, except for ones with recreational marijuana laws. CBD has been reported to assist certain health issues in a more holistic way. CBD reacts with a user’s Endocannabinoid System (ECS) a series of receptors and enzymes that can create potential positive effects on various regulatory processes of the body. But wait a minute, is CBD even legal?

Is CBD legal? What about THC?

This question is important to answer as there is a general misconception about CBD and whether or not it is legal. The two main cannabinoids of the cannabis plant are CBD and THC. These two are often not separated and not understood to be different. But they are! CBD does not give psychoactive effects to those who use it. Because of this, THC is not considered federally legal. In 2018, the Farm Bill gave farmers the ability to grow hemp in all 50 states. Hemp is defined by the percentage of THC it contains. To be classified as hemp, a cannabis plant contain no more than .3% of THC. So, yes! CBD is legal. If you live in a state that has recreational use of THC, it is important to check labels to make sure that you are getting CBD from a hemp plant, not marijuana, if you wish to be sure that there is less than .3% of the THC cannabinoid.

What is the difference between CBD (cannabidiol) and THC (tetrahydrocannabinol)? 

This is likely the most researched question surrounding CBD, because there is a lot of misinformation out there. CBD and THC are two of the cannabinoids that are derived from the cannabis plant. CBD is often reported to give a sense of calm and THC has a psychoactive effect. There are a handful of states that allow the use of medical marijuana as well. That is the biggest difference between THC and CBD, THC creates the “high” effect and CBD does not produce a “high” effect but may provide a plethora of health benefits. Both of these compounds are utilized by the Endocannabinoid System (ECS) but make the body and mind feel differently.

Why should I use CBD? Are there real benefits?

There are plenty of reasons a person might be interested in using CBD. Here are a few:

Anti-inflammatory traits – CBD has been reported to reduce joint inflammation in many studies. This includes a study done by Panacea Life Sciences that tested dogs with Osteoarthritis. This study reported increased mobility in dogs whose owners administered a certain amount of CBD. You can read more about our study here.

Epidiolex- Some of the benefits for reducing seizure frequency and intensity are being used in conventional pharmaceuticals. Epidiolex is known as the only FDA-approved supplement that contains CBD. Epidolex is used to treat Lennox-Gastaut syndrome and Dravet syndrome which are two types of harsh epilepsy. This treats seizures and is approved to be administered to children and adults two years old and older.

Mental wellbeing- In this study, they found that CBD assisted rats with managing feelings of helplessness and anhedonia (the loss of interest in activities that gave feelings of pleasure or happiness before). We can infer that this would give an over sense of mental wellbeing.

Sense of calm – CBD has been reported by users to assist those who may have an increased sense of anxiousness caused by day-to-day activities. Reviews and reports from CBD users and administrators say that CBD helps them to feel calmer.

Skin health – This study tested skin health across many indicators before and after the use of CBD. It measured elasticity, hydration, and a transepidermal water loss test. Support from this was found in photographic evidence from the study. They found that the administration of a topical CBD ointment may be a positive way to improve skin health for those with or without skin conditions.

What is CBD Hemp Oil? 

Marijuana and hemp are strains of the plant Cannabis sativa. CBD hemp oil is generally extracted from the hemp plant. It is important to know the difference between the two plants, because the marijuana plant is not legal in all states and those products are not available everywhere. Make sure to check the labels on CBD products to see what type of cannabis oil is in it. Cannabis oil and CBD oil have varying amounts of CBD and THC. Cannabis oil is known to have more than the .3% of THC that the hemp plant does. CBD hemp oil is derived from the flowers and leaves of the hemp plant. Cannabis oil is derived from the leaves and flowers of marijuana plants. After extraction, the CBD or cannabis oils are formulated into different types of products. CBD hemp oil, in any form, will not get those who take it “high” whereas cannabis oil has higher amounts of THC and is more likely to get users “high.”

Are there different types of CBD oil?

Yes, there are different types of CBD oil! One may be better tailored to you and your needs. There are three major types of CBD oil. Here is a break down:

It may be beneficial to keep these three types of CBD oil in mind as you shop for the right oil for you. It is important to note that a CBD oil that is labeled full-spectrum still does not have the ability to create a “high” in users.

What are the different types of CBD products?

There are various types of products that contain CBD. Choose a product based on how you intend to use it. Other CBD products besides oil include:

Softgels or capsules: Instead of using an oil that directly leads to the bloodstream through the mouth, softgels or capsules are available to take orally. After taken orally they are broken down by the stomach and then enter into the bloodstream through stomach tissue. This is an easy way to get a daily, accurate intake of CBD. This way of taking CBD lasts considerably longer but takes longer than a tincture to begin.

Edibles: This way of using CBD is similar to a softgel or capsule. You can add CBD oil to your favorite snack or try out gummies for a daily ingestible. This way also takes longer to feel the effects, but, lasts longer also.

Balms: The skin has the lowest bioavailability therefore when using a CBD balm or salves it is imperative that the use is consistent to get the full benefits. Apply allover for a full effect or in one area to reap the benefits of localized skin maintenance.

Vapes: Although Panacea Life Sciences does not endorse the use of vapes, it is an option for CBD use. This way of using CBD has the highest rate of absorption as it is directly entering in the bloodstream via inhalation. That being said it is important to note that the effects are shorter-lived and there have been reports of injuries associated with vaping.

Are all CBD products created equal?

The short answer to this question is no. Not all CBD products are created equally. This is because often products are not created in the same way. Like we have previously stated, there are different types of CBD and they can come from different sources. It is crucial to read about the product before purchasing it. There may be lingering or harmful ingredients in a CBD product. The quality of a product can create a positive or negative experience for users. Here at Panacea Life Sciences, we test our products extensively to assure the highest quality for our customers. Some of these tests include: a third party classification test, potency test, toxin test, microbe test, terpene test, and solvent test. You can read more about these tests here and use the QR code on the back of our packaging to view the third party lab test performed on your Panacea product.

Who can use CBD Hemp Oil?

Furry friends, people, and possibly children can use CBD hemp oil. There has yet to be many studies done on CBD as the main focus has been on THC instead, because of the psychoactive effects it exhibits. We recommend speaking to a veterinarian or a healthcare provider before partaking of any type of CBD. There may be interactions when CBD is taken with some types of medication. There have been reports of CBD assisting in joint mobility in canines. People report positive benefits as well.

Where can you get CBD Hemp Oil?

The places one can purchase CBD hemp oil depends on where you live and the type of access you have. There are many different online retailers that provide CBD oil. To choose an online retailer may be a daunting task because there are so many. It is imperative to do your research before purchasing any CBD hemp oil. Like we stated earlier in this article, not all CBD is created equal. Besides online retailers, there are also storefronts that provide access to CBD products of all types. The in-person treatment may be useful to some. If you live in a state where recreational marijuana is legal, you may find CBD products at dispensaries. Make sure to look at the THC amount to ensure that it is the right fit for you and your situation.

Conclusion 

We have covered a mass amount of information on CBD hemp oil and hope that you now feel comfortable continuing on your journey with CBD. To reiterate, CBD is the non-inebriating aspect of the cannabis plant. There are multiple specific reasons to use CBD or you can use it to enhance your overall wellbeing. We have covered the types of CBD oil and what they mean, how to use it, and who can use CBD. As always, it is important to speak with a health care professional before taking or administering CBD.  If you have any comments or questions on CBD feel welcome to email us at [email protected] or call us at 1 (800) 985-0515.

Links:

https://www.agriculture.senate.gov/2018-farm-bill

https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-comprised-active-ingredient-derived-marijuana-treat-rare-severe-forms

https://panacealife.com/cbd-theapeutic-option-for-canine-osteoarthritis/

https://www.sciencedirect.com/science/article/abs/pii/S0031938418307509

https://www.clinicaterapeutica.it/ojs/index.php/ClinicaTerapeutica/article/view/377

https://www.sciencedirect.com/science/article/pii/S0025619619300072

https://panacealife.com/see-test-results/

What about Acne and CBD?

The skincare industry is absolutely booming right now. More and more people are now realizing the benefits of working on their skin’s health and condition with new products popping up all over the place to meet this demand. It seems that we can’t go one month without a new hero product or superfood appearing that is supposed to solve all of our problems. CBD for acne may just be another one.

One skin condition that causes a lot of people grief is acne. Many of us are familiar with acne as a condition, but not necessarily what causes these skin blemishes. Acne is a skin condition where follicles are clogged with oil or dead skin cells. This causes a skin immune and inflammatory response resulting in the red inflamed and often pus-filled lesions we associate with Acne. Acne most commonly appears on the back, face, or shoulders, as the Mayo Clinic points out. It occurs in people of all ages and may be affected by one’s diet, skincare, emotions, and hormones.

A particular group of people that are a general target for acne are young adults and teenagers. As most of you reading this will know, it may be severely distressing to have a visual skin condition at this point in your life.

Researchers are exploring new ways of tackling acne and help the process to lessen symptoms as well as minimizing scarring that this condition commonly causes. One of the best things about the skincare industry is that it’s full of creative minds and innovators who are always looking to create new and helpful products.

One ingredient in skincare that’s received a lot of traction recently is CBD. This natural ingredient may be found in a wide variety of interesting personal care products ranging from makeup palettes and sprays to moisturizers and tinctures. The skincare community is becoming more and more open to using CBD as it has a wealth of benefits.

In today’s blog post, we’re going to be taking a look at how CBD products may be used for acne and as a skincare product in general. It’s truly an emerging hero of the skincare and beauty world, and here at Panacea Life, we’re big fans of how CBD supports skin health- which is why we offer so many CBD products on our website.

Whether you’re looking to learn more about CBD as a product, the reasons for using CBD products as a whole, or how it could help acne sufferers, we’ve got you covered.

What is CBD?

To make sure that we’re all on the same page, let’s take a look at what CBD actually is.

This natural and organic compound is found in the cannabis plant. If you’d like to know general information regarding CBD check out our other more detailed article here. CBD is not psychoactive, so it doesn’t get you intoxicated like cannabis does and has a wealth of reported health benefits.

The most common form of CBD is CBD oil. This oil is made by extracting CBD from the cannabis plant and mixing it with a base oil. Base oils such as coconut oil and Hemp seed oil are most typically used in formulating CBD to the appropriate concentration and method of dosing. CBD oil may then be manufactured into finished goods such as soft gels, tinctures, edibles, and topicals.

What personal care products contain CBD?

The list of products that you may find with CBD is constantly growing as more and more companies are recognizing CBD’s positive effects on skin health. Some of the most intriguing products that may be found available to purchase on the market right now include;

This list is not exhaustive by any means. There are new and exciting products being developed and launched daily by skincare and beauty companies. There are additional industries launching creative products containing CBD.

If you’re looking to explore how you may incorporate CBD products into your health regimen, we’d recommend taking a look on social media to gain more insight. There are social media posts daily on how people are using CBD products for positive health benefits, and you’re bound to find some interesting influencers online to help out with your CBD journey.

Why do people use CBD products?

CBD is also gaining attention for improving mental well-being. People experiencing anxiety are exploring CBD to produce a calming effect as an alternative to debilitating prescription drugs. As Medical News Today notes, CBD may be used by people experiencing a number of different anxiety issues, including panic disorder, Obsessive-Compulsive Disorder (OCD) and Post Traumatic Stress Disorder (PTSD), to great benefit with minimal side effects.

The main reason why anxiety sufferers are using CBD is that it reportedly produces a calming effect without any clouding of mental function. CBD products manufactured from industrial hemp have little to no THC in it. This is great for people with anxiety issues, as THC may heighten anxiety and make them feel worse. CBD has been reported to produce a calming effect, so maybe a great alternative to help people cope with anxiety and focus on daily life issues.

Another reason why people use CBD products are reported wide-ranging health benefits. People who suffer from chronic illnesses or are dealing with an injury often use CBD oil and creams as an alternative to over the counter analgesics or opioids.

CBD is also being explored for its anti-inflammatory properties, which brings us back to the main topic of this blog post. CBD’s anti-inflammatory activity may be the foundation why CBD has been reported, both in scientific research articles as well as social media consumer posts, to help with a wide range of health conditions, including acne. We’ll be exploring in more detail at how CBD may help with acne, in particular later on in the blog post.

May CBD be used for acne?

As we’ve stated already, CBD is sweeping the skincare world by storm. There are a large number of cannabis and CBD related products available on the market currently, and you’ll have many possibilities for choosing your CBD provider and products.

So, may CBD be used for acne? It’s possible, but research at the time of this article is still being explored. There are some intriguing studies, like this 2014 study published by the Journal of Clinical Investigation, that showcase how CBD may interact with the body’s chemistry to reduce the production of sebum that may encourage acne build-up and lower the inflammatory response that results in skin lesions and pustules.

CBD products are very soothing and may help to promote healing in the skin. This is great for calming sore acne points and reducing the buildup of scars. This is why so many makeup companies are currently promoting CBD in their facial serums or oils.

Other important things to know about using CBD products

To finish up this post, it’s important to note some key elements that CBD users should be aware of when using these products. Generally speaking, CBD oil and other products are very handy and positive tools for health, but there are some issues to be aware of.

When searching for your CBD provider, make sure that the company provides certification of the CBD content and purity of the product. Many companies will promote hemp seed oil as hemp oil in their products. Hemp seed oil does not contain CBD. Multiple consumer protection groups have reported that up to 70% of CBD products do not contain the amount of CBD contained on the label, which will lower the beneficial effects that CBD may provide. Here is a link to a presentation that Rosemary Mazanet presented to the FDA regarding these findings in June 2019.
An additional point to bear in mind is that synthetic CBD products may be quite harmful. There have been reports of acute poisoning linked to fake CBD products, as this eye-opening report notes. This is why it’s so important to research your chosen products and the company that you’re buying from, too. Panacea Life has implemented industry-leading quality control to ensure all products provide the highest quality of CBD products, and with test results for each product available for review.

Although CBD derived from industrial hemp is federally legal, there may be local If you’re not sure about the local laws and legislations where you live, please make sure to research them before you buy and use any products. It’s important to do your research here.

How Panacea Life could help you today

As you may see, CBD products are incredibly useful for a number of possibilities. Whether it be anxiety management, reduction of stress levels, clearing up the skin, or other items, exploring CBD as a natural product choice is open to you.

If you are looking to use CBD or cannabis-related products in your own skincare routine, we’d advise you to do your research first. Make sure that you’re buying from a trustworthy, verified company who doesn’t use harmful synthetic ingredients, and that you know the local and national laws about using CBD products in your area.

If you’re looking for a place to buy wonderful, natural CBD and Hemp products, Panacea Life has you covered. We’re extremely passionate about formulating and manufacturing natural, organic products for our customers and helping them to live their healthiest lives possible. Panacea offers a wide range of products available on our website, take a look here.

Additionally, if you need to find out more about what we do or the products that we offer, we’d be more than happy to speak with you. Please feel free to get in contact with us at [email protected] or speak to us through our website here today.

Reference Links:
Acne
CBD vs. THC
Everything you need to know about CBD oil
CBD for Anxiety: Should I Try It?
Cannabidiol exerts sebostatic and antiinflammatory effects
Dubious and dangerous CBD products on the market
7 Benefits and Uses of CBD Oil
CBD Legal History in the US

Vegan CBD Gummies

Let’s cut to the chase: where can’t you find CBD?! 

Walking into your favorite coffee spot before the passing of the 2018 Farm Bill (we’ll get back to this later) was a much different experience than the one you might encounter now. Instead of the usual bagels and day-old muffins lining the shelves and adorning the display boards, Cannabidiol (CBD) seems to have seized the spotlight.

Whether it be adding an oil or tincture shot to your morning beverage of choice, indulging in an additional CBD-infused goodie like chocolate truffles, or even purchasing your very own oil bottle—CBD is popping up everywhere in a seemingly boundless number of forms, making the dynamic product one worth celebrating. Hooray for creativity! 

Go for the Gummy Gold

The ever-trendy and ever-abundant CBD gummy is among the more popular choices. These playful little treats are not only popular in the CBD community, but the vegan community as well. 

If you are vegan, vegan-curious, a conscience eater, or any which way you choose to live your life, CBD is just as accessible to you as, say, your favorite non-dairy milk. But before we begin explaining just why exactly the gummy has us jumping for joy, let’s get some background info on this whole CBD craze. 

What is CBD?

Cannabidiol, affectionately known as CBD, is a naturally occurring chemical compound sourced from plants of the genus Cannabis, namely the hemp or possibly the marijuana plant. It is one of the two most prevalent of 113 identified cannabinoids found in the cannabis plant. The other most prevalent is tetrahydrocannabinol (THC). While both compounds are molecularly similar to your body’s endocannabinoids and thus able to interact with your cannabinoid receptors, they produce very different effects. 

THC binds with sturdy ease to the cannabinoid (CB) receptors in the brain, producing feelings of euphoria. This “euphoric” experience is what we call a “high,” and is the reason we refer to THC as psychoactive. 

Cannabidiol, on the other hand, is non-psychoactive. It is unable to bind as tightly with the CB receptors as THC is. The result is an experience of calmness and relaxation, unlike the mind-altering, high THC yields. 

Why Use CBD?

There are a multitude of reasons more and more people are choosing to add CBD as a supplement to their supplement routine or even replace components of their routine in exchange for the potential benefits cannabidiol may offer. One major factor driving people to do so is CBD’s lack of side effects in comparison to those prescription drugs often produce. On top of that, it has been suggested that CBD is a safer, non-addictive alternative. According to the World Health Organization, “… CBD exhibits no effects indicative of any abuse or dependence potential… To date, there is no evidence of public health related problems associated with the use of pure CBD.”   

While more research is necessary in continuing to unveil the precise mechanisms of CBD, current research has jumped at the opportunity to study cannabidiol in a number of varying contexts. Due to the fact that CBD interacts with the endocannabinoid system, it is no wonder researchers were curious to explore whether the chemical compound’s interaction might alleviate or improve certain systems regulated by the endocannabinoid system, including sleep, appetite, pain and immune system response.1 

To no one’s surprise, an influx of promising findings has continued to stream in from the academic world. 

A number of studies have reported that, due to the endocannabinoid interaction, CBD may help reduce inflammation, a common cause of bodily discomfort.2 One study in particular assessed participants with rheumatoid arthritis and their response to a CBD and THC supplement. Researchers reported improvements in participants’ sleep quality, pain during movement, and pain while at rest. 

Another area researchers have been eager to dive into is mental wellness. A number of studies have suggested a possible benefit to the use of cannabidiol with anxiety and depression. One example is a study in which participants were sorted into a placebo group, while two control groups receivied either 300 milligrams (mg) or 600 mg of CBD. Researchers then measured signs of anxious feelings in participants during a simulated public speaking test. It was reported that the 300 mg group exhibited the most significant reduction in anxiety. 

Clinical research has also researched the potential of CBD to aid children with post-traumatic stress disorder (PTSD), successfully providing relief from stress and inability to sleep, related to the children’s PTSD-induced insomnia and anxiety.  

We could go on and on, citing studies demonstrating the potential benefits of cannabidiol, but to keep things moving and get to the gummy stuff—I mean, good stuff—we won’t. Rather, we will simply share that in addition to these findings, studies have also reported potenital in CBD’s ability to reduce or relieve discomfort related to acne, epilepsy, migraines, drug dependence, multiple-sclerosis, Parkinson’s, chemotherapy-related nausea and vomiting, and more. On the flipside, research has also suggested CBD may fight against disruptive issues related to heart health, diabetes, immune system responses, and more.3  

Let’s Get to the Gummies 

Now that you understand some of the possible benefits, you’re likely eager to start your own little research study, right? We understand—it’s exciting stuff! And who wants to hold off getting their hands on something that may improve their quality of life?

There are a number of ways to self-administer CBD, all worthy of a look-over and all unique in their (occassionally subjective) upsides and downsides. But let’s start with the obvious one:

Gummies!   

Much like the cutting-edge research, we could go on and on raving about these little drops of heaven. Not only are they small, easily transportable, and easy to eat with the flick of a lid and quick pop in the mouth, they come in an array of delicious flavors, shapes, doses, and formulas. 

The three types of CBD formulations in gummies are CBD Isolate, meaning no funny business, just pure CBD without other cannabinoids or THC. Broad-Spectrum CBD, containing CBD and most cannabinoids, but zero THC. And lastly, Full Spectrum CBD, containing all the cannabinoids available from the hemp plant, including THC.

While there are a ton of commercially available products, the Federal Drug Administration (FDA) has not yet approved any over the counter (OTC) products.4 Why? Well, despite the fact that CBD is federally legal (remember the 2018 Farm Bill? This is us getting back to it,) this legalization only applies to products derived directly from hemp and consequently contain no more than 0.3% tetrahydrocannabinol. Laws vary state by state, so it’s important to check your state’s laws and speak with a medical professional about the best way to obtain a safe, quality product.

One of the most exciting aspects of the gummy is its variety. The options are so fun and so endless you feel like an adult in a candy shop. 

Hop on over to the nostalgia-inspiring side with flavors and forms like sour apple, citrus punch, gummy bear or even gumdrop! Take a stride to the other side and explore the assortment of mellow, natural options. Do gummies made wholesome with ginger, vanilla, and lemon pique your interest? How about spirulina, turmeric, and a lingering hemp flavor?

While this multiplex of mouth-watering flavors swirls into a conglomerate of colors before your mind’s eye, let’s address the question in bold lingering before that colorful backdrop: 

What About Us Vegans?

 

Good news vegans, gluten-free eaters, mindful eaters, eaters of all kinds! You are in luck. Not only is there a surplus of natural, organic, gluten-free, allergy-free gummies, there are vegan ones, and plenty of them! 

A great deal of companies carry entirely vegan products. As well, we continue to see an increasing trend of companies introducing vegan gummies to their product lines in an effort to keep up with the broad and inclusive selection many companies today are striving to offer. Thanks to this trend, there is easy access to safe, quality gummies for all, and vegans need not fear missing out on all the fun. Vegan gummies come in just as many diverse and tasty flavors as non-vegan gummies. No more having to choose between your dietary choices and what is arguably the best part—the flavor! You can have your gummy and eat it too. 

A great product to start out with is Panacea Life Science’s Vegan Cherry Bomb Gummy for a number of reasons. Firstly—it’s vegan, duh. Secondly, it maintains the spunky and funky flavor people look for in a gummy. Lastly, it is guaranteed safe, quality product. Packed into this ravenous-red, scrumptiously pop-able gummy is 20 mg of their CBD therapeutic formula. Need I say more?

Are There Other CBD Vegan Products?

Absolutely.

In so many words, this is a great time to be vegan.  After decades of limited, hard-to-find, or just plain bad options for vegans, the diversity and accessibility of options is increasing, and rapidly. We are seeing more products and even entire aisles dedicated to vegan foods at grocery stores. An increasing number of restaurants are including vegan options in their menu. Fast food chains and other big names are even jumping on board, such as Burger King’s Impossible Burger or Tyson’s Beyond Meat vegan brand. From grocery stores to restaurants, award shows to beauty products, the market is clearly (and finally) catching up to the consumer’s demands, and when that demand represents a 300% increase in veganism over the last 15 years, the market wastes no time catching up. 

 

Reference Links:

Footnotes
1. Endocannabinoid system: An overview of its potential
2. Pharmacotherapeutic considerations for use of cannabinoids
3. 7 Benefits and Uses of CBD Oil
4. Top 10 CBD Gummies

Other
5. CBD vs. THC: What’s the Difference?
6. Preliminary assessment of the efficacy, tolerability and safety of a cannabis
7. Cannabidiol presents an inverted U-shaped dose-response curve
8. Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia
9. Cannabidiol (CBD)-what we know and what we don't
10. The Best CBD Gummies
11. IS CBD OIL LEGAL IN ALL 50 STATES?
12. New Study Reveals 9.6 Million Americans Are Vegan Now
13. OSCARS 2020: ACADEMY AWARDS TO BE ALMOST ENTIRELY VEGAN

Why Choose CBD Gummies

In general, most people have consumed candy in their life. There are plethora of types of candy and gummies are just one of them.They come in a variety of shapes and sizes but are recognizable and give us a sense of familiarity. 

2013 was the year Charlotte Figi showed all of us the health benefits CBD (the compound Cannabidiol) may have to us. At only five years old, this little girl was on her death bed with a condition called Dravet Syndrome. Dravet Syndrome is an intense condition that made her suffer from frequent and drawn-out epilieptic seizures. Figi’s parents drained all the medical pathways attempting to assist their daughter. Then they found a type of Cannabis that was low in THC but high in CBD and stopped her harsh seizures in its tracks. 

This five-year-old girls situation displayed one of the many amazing benefits of CBD. The studies on cannabinoids are slim pickings because Cannabis has not been legalized in many countries. It nearly became hopeless to acquire funding to clinically research the potential medical benefits of Cannabis including CBD. This was all because of the United States 1970 Schedule 1 classification of Marijuana that took a large hard hit on the process that could have followed. Nonetheless, a type of evidence that would be titled as anecdotal along with scientific research more than has been seen ever before guides toward multiple of Cannabinoids (including CBD) that may be an option for types of medical issues. Also, in addition to the recreational use tied to wellness and health benefits. 

One of the most popular and best ways of taking CBD is through gummies among the plentra of choices you may see. We’ll start with talking about CBD and what it actually is then we’ll explain how it differs from THC. 

THC and CBD

Cannabidiol, or for short, CBD is a compound found among many others that is found in Cannabis and Hemp plants. It is likely that you have heard of THC (tetrahydrocannabinol) which is the most well known compound of Cannabis because it is known for its psychoactive or “high” feeling that is associated with the use of Marijuana and Cannabis. The compound that is not psychoactive, CBD, does not have the effects that THC does on the brain. Rather, the Endocannabinoid system is what it works with that assists the body functions that maintain the balances in the body.

 Generally, CBC is taken from the Hemp plant which is the type of Cannabis that consists of organically lower amounts of THC (legally 0.3% of lower). These minuscule amounts of THC have no apparent effects that are deemed psychoactive. The agricultural growth of Hemp in the United States for the commercial use is legal in nearly all states. The Agriculture Improvement Act or “Farm Bill” in 2018 took out the Hemp plant from the Schedule 1 of the Controlled Substances Act. 

Choices, choices: What type of CBD should you take?

 Depending on a user’s goal for using CBD, it can be taken in a number of forms. One of the most seen forms of using CBD is in smoking the cigarette-like ‘blunts’ but this is the most coarse method and it does not completely exclude the small amount of THC. CBD can also be smoked in water pipes (bongs) or regular pipes. 

Luckly, CBD is able to be taken from Marijuana and Hemp plants alike. Then, when it is correctly processed the pureness of most is about 100% CBD. The extracts or isolates of CBD can be used then in a number of different ways. 

There are options such as topical ones. Topical options include creams, lotions, serums and salves that are infused with CBD then are applied on to the skin and it may help with pain and inflammation for specific areas. An oil type of CBD is available to use by adding it to a number of foods, mixing the oil with drinks or use as-is by putting the oil under the tongue. A very popular and simple way of taking CBD is purchasing or even making edible types of CBD. Edible types include baked goods, gummies and even hard candy. 

Important things to understand about CBD Gummies

Gummies infused with CBD are created similarly to the gummies you would purchase at a store, but, with amounts CBD in every piece. The ingredients generally include gelatin or jelly mix, different sweeteners and flavoring along with coloring. 

Often gummies made with Cannabidiol could or could not contain amounts of THC. This depends on the labels put on by the manufacturer and the state that you purchased the CBD gummies in. THC is currently only for sale as recreational in 11 of the U.S. as well as Washington D.C. The amount of infused extract that is put into CBD gummies can contain Full-Spectrum which means all of the aspects including all Cannabinoids of the Hemp plant are present. The effect titled as the Entourage Effect is then created which assists to increase the therapeutic benefits. But, a CBD option can also be Broad-Spectrum which includes no compounds of THC or it uses a pure type of CBD isolate. 

The amount of CBD in gummies can be lower but others may have higher amounts. A few gummies could even add different ingredients that may help with overall health, for example, adding melatonin for sleeping. Reading the label is of high importance as, like stated before, the amount of CBD in each gummy product may vary. 

Naturally, Cannabidiol has a bitter taste, therefore, adding sweetener is quite common. There are manufacturers that like to use artificial sweeteners in their gummy products but others may use corn syrup or a type of natural sweetner that could include beet or cane sugar. There are also a variety of CBD gummies made for vegans. Vegan gummies are made from agar rather than gelatin that is derived from seaweed. When you go to purchase gummies make sure to read the label if you have a specific type of sweetner you’d prefer. 

CBD gummies? Why take them? 

Gummies infused with CBD are extremely popular because they are an easy and fun way to ingest CBD. Besides the wellness benefits CBD gummies may give they are a great choice for the reasons following: 

Choices of CBD: What should I look for while purchasing CBD gummies? 

The choices of CBD may be overwhelming and confusing to users. Because of all the information on Hemp, Cannabis and the extracts they contain. Use these factors to decide what type of CBD gummies to buy: 

Ingredients – Generally, CBD gummies contain sweeteners among other ingredients that increase the appeal. Paying attention to the ingredients in a CBD gummy is of crucial importance. Perhaps you’re allergic or do not want to ingest certain ingredients. 

Legal Information – CBD is federally legal in all of the United States since 2018. A few CBD gummies may contain THC which is not legal in all of the states. 

Strength – This is referring to the potency of CBD products. CBD products are measured in milligrams per unit weight. A standard gummy is 5 mg and considered mild but 10-25 mg is average for most users.

Source – CBD isolate contains no amount of THC but it lacks other Cannabinoids that may be beneficial to your body. More wellness benefits come from the use of a broad-spectrum CBD type, so purchase gummies with broad-spectrum Hemp infuse. But Full-spectrum infused gummies contain the most Cannabinoids, so users should be aware that it will likely have a slight level of THC and may not be available for purchase in certain states.

THC amounts – A gummy that is made from pure CBD isolate will not have THC the compound that creates a ‘high’. If you don’t want any amount of the high make sure you purchase THC-free gummies. Depending on where you live, you may not be able to purchase gummies with THC.

The FDA does not authorize third-party testing data for CBD gummies and other supplements so it is important to be aware that some CBD products may have ingredients of claims that the FDA does not support. Solid, responsible manufacturers usually hire third-party testing and provide the results so the consumer has the best information available in regards to claims of potency and impurities.

Common questions asked about CBD gummies:

Do CBD gummies have side effects? 

The FDA has said that CBD gummies, soft gels, and other CBD choices as “generally recognized as safe” (GRAS), which means that experts believe that one can consume CBD gummies without being of risk to your health. The Mayo Clinic states that CBD is safe for use it may cause mild side effects in some people. These may include dry mouth, diarrhea, reduced appetite, and fatigue.

Can I give my pet CBD gummies?

All mammals, as well as pets like cats or dogs, also have an Endocannabinoid system that CBD regulates. Gummies are not recommended for pets. With that being said, there are other products, like soft gels, that are easily administered to your pet. You can make a small hole in a soft gel, and squeeze the contents inside your pets jawline, or perhaps hide it in their food. CBD products may also assist in calming anxiety, reducing pain, and may help other wellness problems your furry companion could be dealing with. It is most likely you’ll find pet-friendly treats when searching for them. But it is more likely that other forms like oil or CBD-infused treats will be found. 

What about my anxiety and CBD gummies? Will they help?

Yes. CBD works in the endocannabinoid system in a person’s body to calm nerves and may help moderate hyperactivity. Assisting symptoms of anxiety are one of the significant and more common uses of CBD. Anecdotal evidence from those who use CBD and a few research studies explain that people diagnosed with anxiety may use CBD to shrink physical symptoms of anxiousness and may help the body relax.

Can I give my child CBD gummies?

Charlotte (the five-year-old from the story above) was given CBD at such a young age because her parents didn’t have many options. Recently, the FDA approved a drug called Epidiolex to treat Dravet syndrome (the one Charlotte had) and another form of harsh epilepsy that began in childhood. This is the first drug comprised of an active ingredient found in Hemp and Marijuana, CBD, that has been approved by the FDA so far.

CBD is generally regarded as safe by the FDA, because of this, some parents are opting to give their kids CBD gummies to help with symptoms of anxiety, insomnia, ADHD, and other conditions. Although there isn’t a large concern for children using CBD, it is important that you make sure that the CBD comes from a reputable company and does not contain THC. Always consult with your health care professional before administering any CBD product to children.

Will gummies containing CBD get me high?

Generally, the answer varies depending on the type of CBD gummies you have purchased and consumed. Hemp and Cannabis contain over 500 Cannabinoids, which only 104 of them have been identified and studied. The ingredients that are active in CBD gummies are Cannabidiol (CBD) and 9-Delta-Tetrahydrocannabinol (THC).

With that being said, THC is the primary phytocannabinoid known to cause psychoactive effects or the “high” and is the substance that makes Marijuana illegal in some states. Hemp in the United States contains less than 0.3% THC, which is not enough to feel any psychoactive effects, and is legal as of 2018.

Now what? 

CBD gummies are a yummy and easy way to consume CBD. They are available in plenty of flavors, may contain added ingredients to benefit your body, and can be carried and eaten anywhere if needed. After reading this, you may now have the confidence and information to purchase CBD gummies and maybe start to experience the health and wellness benefits you’ve read all about. Our CBD gummies for sleep will help you relax and enjoy yourself. Check them out in our shop!

Reference Links:

How to find the right CBD pill for your dog

Dog owners may get stressed out when their canine friend is sick; some will spend a lot of time researching and seeking a solution for their dog.

Recently, Cannabidiol (CBD) has been the stand out medicine for pets around the globe. Many dog owners have recently started to use CBD pills for their pets because of their potential health benefits.

 

What is CBD?

Cannabidiol found in hemp is a non-psychoactive compound which most people refer to as CBD. It is among those naturally occurring cannabinoids substances found in Cannabis.

Before we discuss the benefits of CBD pills for dogs, let’s get some background on it, started with some basic facts.

There are several species of the Cannabis plant, but hemp is the plant that is usually used to extract CBD. Your dog can’t get high on CBD as it has no psychoactive effects, unlike its well-know cousin Tetrahydrocannabid (THC). THC can be found in certain CBD products, but if present is at such small concentrations, it is unlikely to cause any problems.

 

How CBD was discovered

Cannabis has been used as a health supplement for a long time. The first recorded use was in 2727 BC. It was used by Emperor Sheng Neng of China to help him with different health issues like malaria, gout, and poor memory; he was usually served Cannabis-based tea.

In 1940, chemist Roger Adams successfully extracted CBD from a strain of Cannabis. After this extraction, research started on what exactly CBD may do.

In 1960, the Israeli organic chemist Raphael Mechoulam officially proved that CBD is a non-psychoactive part of Cannabis.

Today, there are several companies dedicated to manufacturing CBD for beneficial use, not just for humans, but for pets as well.

 

Is CBD legal?

Many dog owners know the health benefits of CBD, but they may be rather skeptical about CBD legality because they know it’s been derived from the Cannabis plant. If your veterinarian recommends CBD for your furry friend, don’t worry. CBD products are legal if derived from industrial hemp. 

The United States has recently made progressive changes in its Cannabis laws. Many states have legalized all Cannabis for medical use, while 11 have legalized it for all uses. Of course, that is just referring to Cannabis in general. Hemp products (like CBD pills) have been legalized federally, meaning that it is available in all 50 states.

 

How it works

There are two main receptors that are produced in the body and interact with the compounds in Cannabis, and they are CB1 and CB2. CBD affects the body by interacting with these receptors. CB1 is located mainly in the brain. The receptors are responsible for coordination, pain, memories, appetite, and other functions. As CB2, they are usually found in the immune system. They tend to affect inflammation and pain. This is the same for people and dogs.

Those CB1 and CB2 receptors are part of the endocannabinoid system. It is found in most mammals, including furry friends. This is why CBD pills work in people and dogs.

 

What is the right amount to give your dog?

Dog owners should know that there are many factors that will determine the amount of CBD that will be therapeutic. They should also know that there aren’t any serious side effects associated with dogs and CBD.

There are specific kinds of CBD pills made, especially for dogs. These usually have high-quality ingredients and recommended dosages, which may improve your dog’s health.

It is easy to know when we have to pull back on something we are taking. It’s harder to say that for our pets. Because of this, it is essential that while giving your dog CBD pills, you start with the smallest possible amount. By starting low and then slowly increasing dosages, you will find the right dose that will improve your dog’s health.  

We humans are all different, so are our dogs. That is why every dog owner that wants to use CBD use begins with a small amount and should monitor any changes and adjust from there. Most products have a description of how to use and the dosage, but that your dog may require a different dosage.

 

Keep CBD away from your dog

Like most supplements we use at home, the manufacturer always advises keeping this product away from children. The same also applies to CBD pills and other related products, and you have to keep them so your canine friend won’t eat more than they should.

It is advisable to separate regular treats and food from CBD. Even if CBD pill for dogs does not contain THC, dog owners should be careful where they place this supplement after use. Too much of a good thing may be a bad thing. It is important that you store the pills in a place they won’t get confused for treats or food.

 

Does it take effect immediately?

After the dog has taken the pill, we all want to know when it will start to affect your pup. Well, it depends. When you want to reduce anxiety in your dog, you will notice the effect in the space of 5 to 30 minutes. For effects on joint health and flexibility, full benefits might take a couple of days, maybe even weeks. Sometimes it depends on the dosage amount giving to the dog as well as the severity of the condition your pet is experiencing.  

 

How to find the right CBD Pill for Dog

Before you start giving CBD pills to your dog, always consult your veterinarian for advice, brands, and dosage. Cannabis-related products for pets are generally unregulated, so most dog owners should be careful and keep an eye on the ingredients of the CBD pills.

Any dog owner that wants to purchase these CBD pills should be sure to check for the following:

With these, you are ensuring that the product is made in a clean, healthy environment and made with safe ingredients.

 

Bottom line

Recently we have started to see the importance of CBD in our daily life and how it may improve our pets’ health. It may be effective for dogs, and many veterinarians recommend these pills for dog owners.  

All dogs need attention and care, and every pet owner wants to do their best for their dogs. CBD could be a way to do that.

Reference Links:
www.cbdcentral.com/the-history-of-cbd/

cbdliving.com/collections/cbd-pet-capsules

www.preventivevet.com/dogs/what-to-know-if-you-want-to-give-your-dog-cbd-cannabidiol

Exactus Joins with Panacea Life Sciences to Create Premier living well CBD Platform

Leslie Buttorff, Founder of Panacea, To Lead Combined Companies as Chief Executive Officer. A living well CBD Company.

DELRAY BEACH, FL / ACCESSWIRE / July 1, 2021 / Exactus, Inc. (OTCQB:EXDI) (the “Company”) a leading supplier of living well CBD ingredients (CBD/CBG), today announced the acquisition of Panacea Life Sciences, Inc. Panacea, which was founded by Leslie Buttorff, in 2017 as a woman-owned business, which attracted $20 million in initial investments which were followed up with a $14 million in investment from 22nd Century Group, Inc. (XXII) during 2019, a leading plant biotechnology company focused on technology to decrease nicotine in tobacco plants also uses its expertise for genetic engineering of hemp and cannabis plants to modify cannabinoid levels used in manufacturing CBD, CBG and CBN. 22nd Century exchanged its Panacea preferred stock for a 11.6% stake in Exactus. Exactus Executive Chairman and media executive Larry Wert, will also remain on the Exactus board of directors and resigned as Executive Chairman.

Panacea Life Sciences is a leader in production of legal, trace THC, hemp-derived cannabinoid products for consumers and pets that operates a 51,000 square foot cGMP certified facility in Golden, Colorado and PANA Botanical Farms in western Colorado, complete with fully integrated extraction, manufacturing, testing and fulfillment. Panacea produces soft gels, gummies, tinctures, sublingual tablets, cosmetics and other topicals for purchase online (www.panacealife.com) and in stores as well as in smart kiosk vending machines being rolled out nationally. Through 2021 Exactus produced and sold hemp and hemp-based products from its 200-acre farms in Cave Junction, Oregon well known as a leading region for the production of hemp. Panacea also founded the Cannabinoid Research Center at Colorado State University and supports medical studies designed to evaluate the effects of cannabinoids in human health and wellness.”

“Our focus on quality and traceability are the hallmarks of Panacea’s seed to sale strategy. From our state-of-the art CO2 extraction, chromatography equipment and product manufacturing lines, we can produce as much product as we need to meet our sales goals for the foreseeable future.” said Leslie Buttorff, founder of Panacea. “We first entered the living well CBD arena with a world-class SAP-based ERP system developed for the Cannabis industry by Quintel Management which tracks the full chain of custody for every product, as well as provides all back office and production planning capabilities. We believe this sets us apart from the majority of hemp farms and CBD companies” added Ms. Buttorff who is also President and Chief Executive of the SAP management consulting firm she founded. “Seeing the utter chaos that permeates the emerging cannabis and hemp industry, accurate supply-chain accounting and reporting is crucial to our success. Unlike other companies, we set out to set the industry standard for compliance and reporting, which has been rewarded with our successful partnership and investment in joint technology with 22nd Century.”

“Since the beginning of 2021, we have focused on restructuring and properly positioning the company to execute a strategic acquisition. We are thrilled to have met Leslie Buttorff and the Panacea team as they have developed a real gem of a CBD company.” said Larry Wert, Executive Chairman of Exactus. “Throughout this process, we have evaluated many companies, and Panacea has proven to be superior in all aspects. We are pleased to provide our loyal shareholders this opportunity to continue in the living well CBD arena. I would also like to thank Exactus’ founder and investor Harvey Kesner and Andrew Johnson, who provided invaluable insight and support throughout our difficult transition year and in connection with the Panacea transaction.” In connection with the closing, Mr. Johnson resigned as an officer of Exactus, but will continue on with Panacea to assist with investor relationships.

About Panacea Life Sciences, Inc. Panacea Life Sciences is a woman-owned and woman-led company, dedicated to developing and producing the highest-quality, most medically relevant, legal, hemp-derived cannabinoid products for consumers and pets. Beginning at PANA Organic Botanicals located at Needle Rock and throughout its 51,000 square foot, state-of-the-art, cGMP, extraction, manufacturing, testing and fulfillment center located in Golden, Colorado, Panacea operates in every segment of the living well CBD product value chain. From cultivation to finished goods, the Company ensures its products with stringent testing protocols employed at every stage of the supply chain. Panacea offers the purest natural remedies within product lines for every aspect of life: PANA Health™, PANA Beauty®, PANA Sport™, PANA Pet®, PANA Pure® and PANA Life™.

Transaction Summary:

Under the terms of the Agreement the Company issued 1,000,000 shares of Series C Convertible Preferred Stock, 1,000 shares of Series C-1 Convertible Preferred Stock and 1,000 shares of Series D Convertible Preferred Stock and 473,639,756 shares of Common Stock in exchange for one-hundred (100%) percent of the shares of capital stock of Panacea. Following the closing the name of the Company will be changed to Panacea Life Sciences Holdings, Inc. The Company has also authorized a 1:28 reverse stock split which is pending regulatory approval.

Paradox Capital Partners, LLC, Ft. Lauderdale, Florida, served as advisor for the transaction.

To learn more about Panacea and its products or our land-to-brand practices, please visit https://panacealife.com.

To learn more about Exactus, Inc., visit the website at www.exactushemp.com.

Exactus:

About Exactus Inc. (OTCQB:EXDI) is a leading producer and supplier of hemp-derived ingredients and feminized hemp genetics. Exactus is committed to creating a positive impact on society and the environment promoting sustainable agricultural practices. Exactus specializes in hemp-derived ingredients (CBD/CBG/CBC/CBN) and feminized seeds that meet the highest standards of quality and traceability. Through research and development, the Company continues to stay ahead of market trends and regulations. Exactus is at the forefront of product development for the beverage, food, pets, cosmetics, wellness, and pharmaceutical industries.

Reference Links:
https://www.accesswire.com/653853/Exactus-Joins-with-Panacea-Life-Sciences-to-Create-Premier-CBD-Wellness-Platform

Panacea Life Sciences to be the first premium CBD on a plane, allowed to sell in Denver International Airport.

Denver International Airport will debut two new kiosks of CBD products from the Colorado company, Panacea Life Sciences, providing relief for airline travelers.

GOLDEN, CO, UNITED STATES, May 20, 2021 — Panacea Life Sciences, Inc. (Panacea), a cGMP certified, vertically integrated premium CBD company located in Golden, Colorado, will open two kiosk locations in Denver International Airport’s (DEN) concourses B and C. The kiosks, both located in the center of the B and C concourses, will provide the millions of passengers it sees daily access to Panacea’s Colorado-grown, premium CBD on a plane products.

“As a frequent flier (having flown over 4.5 million miles), I wish I would have had access to CBD for anxiety and stiffness from a long flight” says Panacea’s CEO, Leslie Buttorff. “So today, we are pleased to be the first to offer our high quality and thoroughly tested CBD products to DIA passengers and visitors.”

This airport retail space is a big move not only for Panacea, but for DEN as well. May 21st marks the first time in DEN’s history that they will have CBD on a plane available for passengers and visitors, and Panacea is the perfect company to pioneer entry into this arena. Panacea is a seed-to-sale cannabinoid company with its roots planted at their farm on the western slope of Colorado and at their 51,000 square foot manufacturing facility in Golden. Travelers, whether coming, going, or just passing through, will be thrilled to find therapeutic relief that CBD can provide. Several studies have found that CBD and other cannabinoids have anti-inflammatory properties, so it is suitable to alleviate the stiff and sore muscles, aches, and pains that flying can bring about.

Panacea will introduce over 18 CBD products for topical use including pain relief patches, heating and cooling balm sticks, lotions, lip balm and more. While some may be hesitant to purchase CBD on a plane while traveling, it’s important to know that hemp-derived CBD products are legal in all 50 United States, as long as the products contain less than 0.3% THC – a rule which Panacea follows stringently. While Panacea is leading with their topical products, they anticipate adding their wide variety of ingestible products to the shelves soon. For now, ingestibles (and topicals) can all be purchased on their website at www.panacealife.com. Additionally, the kiosks will sell personal protection equipment like masks and hand sanitizer for these on- the-go consumers.

In order to make this happen, Panacea worked closely with Provenzano Resources, Inc. provides specialty retail leasing services, like carts, RMU’s, kiosks, etc. for companies looking for retail opportunities in shopping malls and transportation hubs throughout the U.S. and internationally. Find Panacea’s kiosk on the southwest side of the center of Concourse C on May 21st, and at their second location on the northeast side of the center of Concourse B which opens on June 10th, 2021.

About Panacea Life Sciences, Inc.
Panacea Life Sciences is dedicated to developing and producing the highest-quality, most medically relevant, legal, hemp-derived cannabinoid products for consumers and pets.

Beginning at PANA Organic Botanicals at Needle Rock and throughout the 51,000 square foot, state-of-the-art, cGMP certified extraction, manufacturing, testing, and fulfillment center located in Golden, Colorado, Panacea operates in every segment of the CBD on a plane product value chain. From cultivation to finished goods, PLS ensures their products with stringent testing protocols employed at every stage of the supply chain. Panacea offers the purest natural remedies within product lines for every aspect of life: PANA HealthTM, PANA Beauty®, PANA SportTM, PANA Pet®, and PANA Life®.

Reference Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/

https://www.einpresswire.com/article/541473340/panacea-life-sciences-to-be-the-first-premium-cbd-company-allowed-to-sell-in-denver-international-airport

Colorado Environmental CBD Company Panacea Life Sciences named Silver Partner by Colorado’s Environmental Leadership Program

Panacea’s focus on providing high-quality hemp products while pioneering sustainable practices earns statewide recognition for continual environmental progress.

“Our full-circle hemp program — where the excess hemp we process goes back into the ground for nutrients — is just one example of our sustainability efforts.”
— Leslie Buttorff, Panacea Life Sciences’ CEO

GOLDEN, CO, UNITED STATES, October 19, 2020 /EINPresswire.com/ — Panacea Life Sciences, Inc. (Panacea), a vertically-integrated environmental CBD company located in Golden, Colorado, is proud to announce their acceptance as a Silver Partner to the Colorado Department of Public Health and Environment’s (CDPHE) Environmental Leadership Program (ELP). The ELP is Colorado’s statewide environmental recognition and reward program for members that voluntarily go beyond compliance with state and federal regulations and are committed to continual environmental improvement. In order for a company to become a Silver Partner, a company must commit to develop and implement environmental management system within an agreed upon timeframe, as well as meet the requirements for “beyond-compliance” activities and programs.

Panacea Life Sciences’ CEO, Leslie Buttorff, explains, “Although we are currently a small company, I believe it is important to exceed the federal and state regulations to find ways in which we can contribute to the improvement of our environment. Our full-circle hemp program — where the excess hemp we process goes back into the ground for nutrients — is just one example of our sustainability efforts.” Panacea is closing in on their pursuit of becoming Current Good Manufacturing Practice (cGMP)-certified as enforced by the FDA, so entering into the Environmental Leadership Program quickly became a natural addendum for the company. Buttorff identified several projects that Panacea plans to initiate in 2021 to increase the company’s sustainability. The projects will focus on the reduction of energy consumption and decreasing pollution, which ranges from gas emissions like ethanol evaporation to waste diversion of spent biomass and/or packaging. One element that will soon have an immediate impact is Panacea’s work toward converting current packaging materials to fully compostable packaging for a number of their hemp products. In doing so, this would create a small but significant effort to move toward better sustainability.

In the relatively new and rapidly growing hemp and environmental CBD marketplace, companies are tasked with finding ways to differentiate themselves. Since their beginning, Panacea has always made it a priority to produce products with integrity whether that means working with state-of-the-art equipment, testing every batch seven times throughout production, or providing third-party Certificates of Analysis to the public. By becoming one of only 33 Silver Partner companies in Colorado in 2020, Panacea is once again setting the standard for the rest of the hemp industry. One of the founding pillars of the company is to enable environmental sustainability, as evidenced by their proactive work with both the Colorado Department of Agriculture and Department of Public Health and Environment. The self-set expectation is to not only ensure compliance with CDPHE’s guidelines but also to establish communication about how they can improve operations while minimizing their environmental impact. As they work on developing an Environmental Management System (EMS), each milestone accomplishment should eventually lead them to becoming Gold Leaders within the next three years.

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About Panacea Life Sciences, Inc.
Panacea Life Sciences, a woman-owned and woman-led company, is dedicated to developing and producing the highest-quality, most medically relevant, legal, hemp-derived cannabinoid products for consumers and pets. Beginning at PANA Organic Botanicals @Needle Rock and throughout our 51,000 square foot, state-of-the-art, cGMP, extraction, manufacturing, testing and fulfillment center located in Golden, Colorado, Panacea operates in every segment of the environmental CBD product value chain. From cultivation to finished goods, we ensure our products with stringent testing protocols employed at every stage of the supply chain. Panacea offers the purest natural remedies within product lines for every aspect of life: PANA Health™, PANA Beauty™, PANA Sport™, PANA Pet™, and PANA Life™. To learn more about our products or our land-to-brand practices, please visit us online at https://panacealife.com.

About CDPHE’s Environmental Leadership Program
The Environmental Leadership Program is a voluntary program that encourages and rewards superior environmental performers that go beyond the requirements of environmental regulations and move toward the goal of sustainability. The program is open to all Colorado businesses, industries, offices, educational institutions, municipalities, government agencies, community, not-for-profit and other organizations. Currently, the program consists of three tiers: bronze, silver and gold.

22nd Century Group Positioned For Growth In 2021 | Drip CB

22nd Century Group Inc. (NYSEAMERICAN:XXII) is positioned for growth in 2021, and the company is currently awaiting MRTP approval from the FDA, which, once given, will allow it to market its VLN cigarettes.

22nd Century awaiting MRTP for VLN cigarettes

The company offers innovative tech and products for cannabis and tobacco industries, and the nature of their business involves genetic modification for mass hemp and cannabis to suit market conditions. 22nd Century’s goal is to make low nicotine cigarettes that will help people stop smoking and contract the growing of the low nicotine tobacco. The company sells its very low nicotine (VLN) cigarettes to the government for research, and it is awaiting Modified Risk Tobacco Product (MRTP) authorization to start selling the cigarettes as healthy alternatives to high nicotine cigarettes. 22nd will roll out the cigarettes within 90 days of receiving FDA approval and leverage opportunities in the potential $800 billion market. Interestingly, VLN products don’t have any competition and could be the future of smoking cessation.

22nd Century leveraging partnerships to expand

Also, the company has entered several partnerships allowing it to leverage its cannabis research and genetics to boost revenue stream. The company wants to introduce its proprietary hemp and cannabis genetic to the market. Their innovative genetics with tailored terpene, THC, and growth profiles promises to make industrial hemp and cannabis farming profitable and more efficient. The company is working with master breeders to develop a database for better data collection. Equally, 22nd Century has several trademarks and patents on their genetic analysis tools for tobacco and cannabis.

For instance, the partnership with Panacea and needle Rock farms will help the company produce and process cannabis genetics and bring them to the market. Most importantly, the company patents its tech, and the products once they come to the market will benefit the company with new revenue streams. In New York, the company grows hemp for research, and they have an endowment with the University of Virginia for research. The company aims to replace tobacco growing with hemp ultimately.

Reference Links:
https://gentrybusinessleader.com/22nd-century-group-inc-nyseamericanxxii-positioned-for-growth-in-2021-as-it-awaits-mrtp-authorization-for-vln-products/

Golden, Colorado Hemp/CBD Company Becomes One of Few in the Industry to Gain cGMP Certificate

GOLDEN, COLORADO, UNITED STATES, March 26, 2021 — Panacea Life Sciences, Inc. (Panacea), a vertically-integrated premium CBD company located in Golden, Colorado, announces its newest accolade of receiving its Current Good Manufacturing Practice (cGMP) certification for manufacturing CBD products.

The hemp industry will soon be regulated by the U.S. Food and Drug Administration (FDA), but because hemp/CBD production was only recently legalized by the 2018 Farm Bill, solid and specific federal regulations are currently lacking. As the FDA plays catch-up with the booming industry, pop-up-shop type CBD CBD companies are able to fly under the radar in terms of manufacturing practices, product quality, and claims made on websites and labels. Unfortunately, these practices have negatively impacted the general population’s perception of what CBD really is and does, which in turn, hurts the companies that strive for the highest standards of practice.

“As the CBD industry matures, we believe the FDA will require GMP certifications to ensure that CBD producers follow proper production practices,” said Panacea Life Sciences’ CEO, Leslie Buttorff. “We wanted to be among the first group of companies to achieve this most notable certification. Not only does it help us hold ourselves accountable — it also assures our customers that a high quality, replicable product is delivered with each and every batch.”

ubsequent to a demanding process that included multiple reviews, inspections, and required upgrades as specified by the federal guidelines, Panacea received their cGMP certification in February 2021 by SGS. As their website states, “SGS is the world’s leading inspection, verification, testing and certification company… recognized as the global benchmark for quality and integrity.” Panacea’s cGMP audit covered all aspects of the production process in its state-of-the-art, 51,000 sq. ft. lab located in Golden, Colorado: materials, premises, equipment, raw material acquisition, storage, record keeping, staff training, hygiene, management of complaints, product development, batch consistency, and more. The time, hard work, and dedication it took from everyone at Panacea Life Sciences is a testament to their already impressive high standards. Being cGMP certified will differentiate Panacea even more as a premium brand that people can trust. It is also worth noting that the “c” in cGMP stands for “current”, meaning that the industry standard is ever evolving, forcing companies to maintain their quality systems. With their consumers in mind – human and pet – Panacea has proven their commitment to going the extra mile to ensure purity, effectiveness and safety of their practice and products.
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About Panacea Life Sciences, Inc.
Panacea Life Sciences is dedicated to developing and producing the highest-quality, most medically relevant, legal, hemp-derived cannabinoid products for consumers and pets. Beginning at PANA Organic Botanicals at Needle Rock and throughout the 51,000 square foot, state-of-the-art, cGMP, extraction, manufacturing, testing and fulfillment center located in Golden, Colorado, Panacea operates in every segment of the CBD product value chain. From cultivation to finished goods, PLS ensures their products with stringent testing protocols employed at every stage of the supply chain. Panacea offers the purest natural remedies within product lines for every aspect of life: PANA HealthTM, PANA Beauty®, PANA SportTM, PANA Pet®, and PANA Life®.
To learn more about the products or land-to-brand practices, please visit https://panacealife.com.

Panacea Life Sciences receives certification as a new member of the Women’s Business Enterprise National Council (WBENC)

GOLDEN, CO – COLORADO, UNITED STATES, February 23, 2021 — Panacea Life Sciences, Inc. (Panacea), a vertically-integrated CBD company located in Golden, Colorado, recently earned its certification as a member of the Women’s Business Enterprise National Council (WBENC). Founded in 1997, WBENC’s mission aims to “fuel economic growth globally by identifying, certifying, and facilitating the development of women-owned businesses.” Led by founder and CEO, Leslie Buttorff, Panacea Life Sciences began in 2017 and has grown steadily throughout its short time in the CBD industry, exemplifying the commitment and tenacity that she possesses as a leader.

Buttorff is no newcomer when it comes to owning and running a business. Before establishing Panacea Life Sciences, she was the president and CEO of Quintel, a provider of Management Consulting and SAP implementation services that specializes in performance improvement for utilities, manufacturing and public sector customers. Her focus shifted toward the CBD industry when she was in search of a more natural pain relief solution to her mother’s fractured pelvis.

At its beginning, the WBENC sought to develop a nationwide certification standard for women-owned businesses, which involves a very meticulous process including an in-depth review of the business and site inspection. WBENC accomplishes their mission through their CORE platform — Certification, Opportunities, Resources and Engagement. “Being certified by the WBENC means we have a great opportunity to provide diversity within the CBD industry,” said Buttorff. “What’s more, the WBENC certification aligns with our Panacea mission and vision to strive for continual innovation so we can elevate the quality of life for our consumers.”

The drive behind Panacea Life Sciences is to cultivate everyday wellness by combining science and nature to offer more organic alternatives to synthetic pain pills. The company has demonstrated this drive by doing things the right way and with integrity; their vertically-integrated, seed-to-sale business model has proven time and again that they produce the purest hemp-based products on the market. Additionally, the company just gained their official cGMP status, elevating the brand even further. Their validity is something that Buttorff says is a major differentiator in the oversaturated industry.

About WBENC
Founded in 1997, WBENC is the nation’s leader in women’s business development and the leading third-party certifier of businesses owned and operated by women, with more than 13,000 certified Women’s Business Enterprises, 14 national Regional Partner Organizations, and over 300 Corporate Members. More than 1,000 corporations representing America’s most prestigious brands as well as many states, cities, and other entities accept WBENC Certification. For more information, visit www.wbenc.org.

About Panacea Life Sciences, Inc.
Panacea Life Sciences is dedicated to developing and producing the highest-quality, most medically relevant, legal, hemp-derived cannabinoid products for consumers and pets. Beginning at PANA Organic Botanicals @Needle Rock and throughout the 51,000 square foot, state-of-the-art, cGMP, extraction, manufacturing, testing and fulfillment center located in Golden, Colorado, Panacea operates in every segment of the CBD product value chain. From cultivation to finished goods, PLS ensures their products with stringent testing protocols employed at every stage of the supply chain. Panacea offers the purest natural remedies within product lines for every aspect of life: PANA Health™, PANA Beauty™, PANA Sport™, PANA Pet™, and PANA Life™.

Reference Links:
https://www.einnews.com/pr_news/535737314/panacea-life-sciences-receives-certification-as-a-new-member-of-the-women-s-business-enterprise-national-council-wbenc